مجلة ديالى الطبية تاسست حسب موافقة وزارة التعليم العالي والبحث العلمي - هيئة الراى في كتابهم المرقم 12س/2433 في 19/8/2010 اذ بدا بعدها اعضاء المجلة باستقبال البحوث العلمية وباختصاصات مختلفة كالعلوم الطبية بفرعيها السريرية والاساسية وطب الاسنان والعلوم الصيدلانية والتي تعالج قضايا علمية وطبية ذات صله وثيقة بالمجتمع العراقي خصوصا والشرق الاوسط عموما. http://148.72.244.84/xmlui/handle/xmlui/2742 2026-04-17T13:13:47Z 2026-04-17T13:13:47Z Marwa A. Al-Badrany Luay A. Al-Helaly http://148.72.244.84/xmlui/handle/xmlui/16754 2025-10-28T06:41:12Z 2025-10-25T00:00:00Z

Title: Changes in the Levels of Methionine Adenosyltransferase, Methionine Sulfoxide Reductase A, and Thioredoxin are Associated with Oxidative Stress in Patients with Hyperthyroidism Authors: Marwa A. Al-Badrany; Luay A. Al-Helaly Abstract: Abstract Background: Hyperthyroidism is associated with increased oxidative stress and alterations in enzymatic and non-enzymatic antioxidant systems. Methionine adenosyltransferase (MAT) plays a key role in cellular metabolism and may be involved in redox homeostasis in thyroid disorders. Objectives: This study aimed to evaluate the levels of MAT and investigate its association with selected enzymatic and non-enzymatic oxidative stress markers in patients with hyperthyroidism. Patients and Methods: A total of 90 blood serum samples were collected from patients with hyperthyroidism and compared with 50 healthy controls. Enzymatic markers measured included methionine sulfoxide reductase A (MsrA), thioredoxin (Trx), catalase (Cat), myeloperoxidase (MPO), lactoperoxidase (LP), xanthine oxidase (XO), glutathione S-transferase (GST), and senescence marker protein-30 (SMP-30). Non-enzymatic markers included glutathione (GSH), uric acid (UA), albumin (Alb), malondialdehyde (MDA), and peroxynitrite (ONOO⁻). Results: Compared to healthy controls, patients with hyperthyroidism showed a significant increase in MAT, Cat, XO, GST, Trx, and LP levels, while SMP-30 was significantly decreased. Among non-enzymatic parameters, MDA and ONOO⁻ were significantly elevated, and albumin levels were decreased. No significant changes were found in the remaining markers. MAT showed a direct correlation with SMP-30, MPO, MsrA, UA, ONOO⁻, and Alb, and an inverse relationship with Cat, XO, and GSH. No correlation was observed between MAT and GST, LP, or Trx. Conclusion: The findings suggest a strong association between MAT activity and oxidative stress in patients with hyperthyroidism. The observed changes point to metabolic imbalances and compromised antioxidant defense mechanisms in these patients.

2025-10-25T00:00:00Z Weaam F. Hussien Estabraq A. R. Al-Wasiti Mahood. Sh. Khudair Hayder A. AL-Aubaidy http://148.72.244.84/xmlui/handle/xmlui/16753 2025-10-28T06:39:35Z 2025-10-25T00:00:00Z

Title: Investigation of Methylglyoxal, soluble Receptor for Advanced Glycation End-products, and Malondialdehyde in Type 2 Diabetes Mellitus with and Without Cardiovascular Risk Factors Authors: Weaam F. Hussien; Estabraq A. R. Al-Wasiti; Mahood. Sh. Khudair; Hayder A. AL-Aubaidy Abstract: Abstract Background: Type 2 diabetes mellitus is a chronic metabolic illness that significantly increases the probability of cardiovascular disorders among individuals with type 2 diabetes. Oxidative stress represents a central pathophysiological connection between type 2 diabetes mellitus and cardiovascular complications. Hyperglycemia in type 2 diabetes mellitus elevates oxidative stress through multiple pathways, including the production of advanced glycation end products and methylglyoxal, which interact with their receptor advanced glycation end product (sRAGE). These processes enhance the generation of reactive oxygen species, which leads to lipid peroxidation with malondialdehyde serving as a biomarker. Objectives: To investigate the levels of methylglyoxal, sRAGEs, and malondialdehyde in type 2 diabetes patients with and without cardiovascular risk factors. Patients and Methods: The cross-sectional study involved eighty patients with type 2 diabetes diagnosed with and without cardiovascular risk factors. The study used high-performance liquid chromatography (HPLC) to measure serum methylglyoxal and an ELISA kit (Sun Long Biotech, China) to measure serum sRAGE. Malondialdehyde levels were assessed by spectrophotometry. Moreover, measured parameters included FBS, HbA1c, CRP, and lipid profile by the Cobas system using a kit from Roche, Germany. Results: Type 2 diabetes patients with cardiovascular risk factors had significantly higher serum methylglyoxal, sRAGE, and malondialdehyde compared to those without CV risk factors. Furthermore, fasting blood glucose, HbA1c, lipid profile, and CRP are higher in diabetes with CV risk factors compared to those without. Conclusion: The patients with type 2 diabetes and cardiovascular risk factors showed an increase in methylglyoxal, sRAGE, and Malondialdehyde, which are considered useful biomarkers for the indication of T2DM with cardiovascular risk.

2025-10-25T00:00:00Z Hayder Mahdi Idan Ghasaq Abdullah Mahmood Ibtehal Qhtan Othman http://148.72.244.84/xmlui/handle/xmlui/16752 2025-10-28T06:36:59Z 2025-10-25T00:00:00Z

Title: Prevalence of Oral Aphthous Stomatitis and Recurrent Herpes Labialis Among Dental Students Authors: Hayder Mahdi Idan; Ghasaq Abdullah Mahmood; Ibtehal Qhtan Othman Abstract: Background: The most frequent oral mucosal lesion is recurrent aphthous stomatitis. It first appears in childhood or adolescence and is evident as many tiny, recurrent, or ovoid ulcers with yellow floors and erythematous haloes. A widespread viral infection, herpes labialis, is characterized by recurrent vesicular lesions, frequently on the lips and perioral tissue. Objectives: To find the prevalence of oral aphthous stomatitis and recurrent herpes labialis among dental students of Bilad Alrafidain University. Patients and Methods: A cross-sectional study was conducted among 187 dental students of Bilad Alrafidain University, who are in the fourth and fifth stages of the dental department. The data were collected using questionnaires. Questionnaires required two sections. The first section restricted personal information. The second section involved questions related to aphthous ulcers and recurrent herpes labialis, including the duration and site of the ulcer after examination. Results: In the present study, the number of students with aphthous ulcers in the fourth stage is 13 (14.1%), and in the fifth stage, 24 (25.3%), with a highly statistically significant difference. Out of 187 students, 10 (10.9%) had recurrent herpes labialis in the fourth stage, while 15 (15.8%) were in the fifth stage, indicating a highly significant statistical relationship. The number of students with recurrent aphthous stomatitis and recurrent herpes labialis in the fifth stage is 24 (25.3%) and 15 (15.8%), respectively, which is higher than in the fourth stage, where the numbers are 13 (14.1%) and 10 (10.9%), respectively, indicating a significant relationship. Conclusion: Recurrent aphthous stomatitis is a lesion with a higher prevalence in females than in males. Stress during the period of academic examinations is one of the reasons for recurrent eruption of aphthous stomatitis and reactivation of recurrent herpes labialis.

2025-10-25T00:00:00Z Iman Najat Ali Najat Jabbar Ahmed Berwary http://148.72.244.84/xmlui/handle/xmlui/16751 2025-10-28T06:34:32Z 2025-10-25T00:00:00Z

Title: Interleukin-20 Gene Polymorphism and Serum Levels of Interleukin-20 and Interleukin-23 in Rheumatoid Arthritis Authors: Iman Najat Ali; Najat Jabbar Ahmed Berwary Abstract: Background: Rheumatoid arthritis (RA) is an autoimmune disease marked by complex causes and ongoing joint inflammation. Recently, more efforts have been directed at finding new non-invasive prognostic biomarkers for RA, which can help in disease monitoring. Objectives: To investigate the circulatory levels of IL-20 and IL-23 in RA patients relative to healthy volunteers and to evaluate their correlation with disease activity. Additionally, to explore the association between IL-20 genetic polymorphism and RA susceptibility. Patients and Methods: The study comprised a total of 85 individuals with RA and 45 healthy subjects. IL-20 and IL-23 concentrations were measured using ELISA, and disease activity was assessed using the DAS-28 score. The IL-20 rs2981573 polymorphism was genotyped using Amplification Refractory Mutation System-Polymerase Chain Reaction. Results: The study found that RA participants exhibited significantly elevated serum IL-23 levels compared to controls (P = 0.0347), while IL-20 levels did not differ (P = 0.6354). Correlations between IL-20 and IL-23 with DAS-28 were significant (P = 0.0021 and P = 0.0030, respectively). Regarding the IL- 20 gene polymorphism, no significant association was found between the rs2981573 gene polymorphism and RA susceptibility Conclusion: This study demonstrated that IL-23 levels were significantly higher in RA patients and may have diagnostic value. Although IL-20 levels were not significantly different between groups, both cytokines showed a positive correlation with disease activity and could be valuable markers. Furthermore, the IL-20 gene polymorphism showed no association with rheumatoid arthritis susceptibility.

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