Relation of C-Reactive Protein with Age and BMI in Diabetic Foot Patients Khalid Shaalansahab

Abstract

Diabetes mellitus )DM( is a chronic disease cannot be cured, and is a combined with serious complications especially after 10-20 years .Diabetic foot (DF) is one of severe diabetes mellitus complications and include ulcers and infection of feet. C-reactive protein(CRP) is an acute-phase protein, rises in the blood as response to infection.The aim of this study is to assessment of C-reactive protein in diabetic foot patients and its relationship with Age and BMI in a sample of Iraqi patients with type2 diabetes mellitus.The study included twenty five (25) diabetic foot patients aged (36-77 years) with type 2 DM (duration ranged from 2-31 years) compared with twenty five patients aged (43-76 years) with type 2 DM without diabetic foot (duration ranged from 1-32 years) as patients control group and thirty (30) healthy subjects aged(42-80 years) as healthy normal control group.Fasting blood glucose and hs-CRP were determined in patients and control groups. C-RP concentrations were assessed by using the Enzyme linked Immunosorbent Assay (ELISA) method. Results: The patients with diabetic foot lesions were found to be poorly controlled and had significantly higher levels of fasting blood glucose (FBG) (p<0.001) compared to patients without diabetic foot lesions and control groups. The patients with diabetic foot lesions were found to had significantly higher levels of C-RP (p<0.001) compared to patients without diabetic foot lesions and control groups. CRP levels were significantly increased in diabetic foot patients with increase of age and body mass index (BMI). Conclusion: Increasing of infection ability according to increasing of age and BMI for diabetic foot patients