INHIBITION ACTIVITY OF PLANT EXTRACT Thymus vulgaris AND Mentha piperita AGAINST Candida albicans

Abstract

The results of this study showed that there was high activity for extract plants Thymus vulgaris and Mentha piperita against Candida albicans ,The infection ratio of Candidiasis that found in Diyala province was 69.3 % . In studying some virulence factors for Candida albicans were the average activity adhence ratio with epithelial cells was 17.5, and activity average Phospholipase %33. The Minimal Fungicidal Concentration (MFC) of antifungal (Flucanazole, Ketacanazole, Nystatin) was 50 μg/ml. AL- coholic extracts (Ethanole70%) for thyme and Peppermint gave better compared to the activity thyme is batter activity than Peppermint extract: In rate 100 mg /ml for the thyme alcoholic extracts (Ethanole70%) give the highest inhibition ratio 100% while in concentration 20 mg/ml for cold water extract Peppermint plant gave the lowest inhibition ratio 66.66%. The concentration 80,100 mg/ml for the alcoholic extracts of thyme and also the concentration 100 mg/ml for alcoholic extracts (Ethanole70%) of Peppermint howed similar activity to Nystatin (2mg\ml) in inhibition of C.albicans