Synthesis and Evaluation of Biological Activity of Several New citraconimides Substituted with Benzothiazoles

Abstract

The target of the present work is to synthesize a series of new Citraconimides containing benzothiazole rings. Syntheses of these new cyclic imides were performed via two steps: The first one involved preparation a series of N-(substituted benzothiazole-2-yl) Citraconamic acids via reaction of citraconic anhydride with 2-aminobenzothiazole substituted with different substituent's. The resulted citraconamic acids were dehydrated in the second step via treatment with acetic anhydride and anhydrous sodium acetate or by fusion method to afford a series of desirable N-(substituted benzothiazole-2-yl) Citraconimides. The synthesized compounds were screened for their antibacterial activity against four microorganisms' including [Staphylococcus aurous and Streptococcus pyogenes] (Gram positive) bacteria and [E.coli and Pseudomonas aeruginosa], (Gram-negative) bacteria respectively. The new compounds were found to exhibit good to moderate antibacterial activity .also anti fungal activity of the prepared compounds were tested against [Candida albicans] fungi and some of the tested compounds were found to exhibit good antifungal activity.