Effect of Zinc and Copper on some immunological markers in Cutaneous Leishmaniasis

Abstract

The elucidative diminished of immune function connecting t the Zinc profile is one of the major highlighted study all over the world. The aim of this study is to evaluated Zn concentration in serum of cutaneous leishmaniasis patients and efficacy on some immunological parameters.A total of 60 patients with cutaneous leishmaniasis (CL) were included in this study during the period between February /2009 to July /2009 in the out – patients clinic of the dermatology department of Azadi General Hospital in Kirkuk governorate.In vitro by using flame atomic absorption spectrophotometer .It was conclude that the mean of serum Zn level in all CL patients were significant decreased (P< 0.05) , since the mean concentration in patients group were 7.61± 0.03 µmol / l, 6.69 ± 0.31 µmol / l , while they were 14.8 ± 0.04 µmol / l, 12.02 ± 0.02 µmol / l in control groups respectively. Analysis of CD4+ and CD8 + T-lymphocyte percentage shows that the mean of CD4+ and CD8 + percentage in all CL patients were significant decreased (P < 0.05) since the mean percentage of CD4+ in patients groups were 36.5 ± 0.098 % , 36.29 ± 0.06% and it was 59.95 ± 0.16%, 58.9 ± 0.14% in control groups respectively .While CD8 + presenting in patients groups were 22.37 ± 0.05 %, 22.47 ± 0.04% , while they were 30.95 ± 0.12%, 31.15± 0.15 in control groups respectively. The mean ratio of CD4+/ CD8+ was significant decreased in male and female patients in comparison with their control groups , since the mean of CD4+ / CD8+ in patients groups were 1.63 ± 0.004, 1.62 ± 0.004 , while they were 1.94 ± 0.01 and 1.9 ± 0.01 in control groups.