Preparation and in vitro Evaluation of Ketoprofen Solid Dispersion System

Abstract

For poorly soluble drugs, such as ketoprofen, the rate of oral absorption is often controlled by the dissolution rate in the G.I.T. Therefore the solubility and dissolution behavior of a drug is key determinants of its oral bioavailability. Several formulations of liquisolid capsules containing two ratios of ketoprofen: Vehicles (1:1 and 1:2) were prepared. In this study the ratio of microcrystalline cellulose (carrier) to silica (coating powder) was 20:1 for all formulations and then changed to 10:1. The dissolution behavior of ketoprofen from liquisolid capsules and conventional capsule formulation was investigated at two different pHs (1.2 and 6.8). The x-ray diffraction ( XRD )of solid dispersion of ketoprofen in ratio of 1:1 was characterized to ascertain if there were any physicochemical interactions between the drug and carrier that could affect dissolution.The results showed that liquisolid capsules demonstrated considerably higher dissolution rate than those of conventionally made capsules. This could be attributed to increased wetting properties and surface of drug available for dissolution. XRD showed a change in crystal structure toward an amorphous form of ketoprofen.