Coated Wire, Coated Graphite and Modified Carbon Paste Electrodes for Potentiometric Determination of Azithromycin

Abstract

For the assessment of the drug azithromycin (AZ) in biological and pharmaceutical samples, three different types of ion selective electrodes were created: the modified carbon paste electrode (MCPE), coated graphite electrode (CGE), and coated wire electrode (CWE). The electrodes followed the Nernst equation in the range (1.0×10-7 - 1.0×10-1 , 1.0×10-6 - 1.0×10-1 and 1.0×10-5 - 1.0×10-1 )M range, with a slope of (58.355, 57.937, and 56,127) mV/decade and a low detection limit of (5.0339×10-8 , 5.111×10-7 and 4.8486×10-6 ) M for (MCPE, CGE and CWE)electrodes respectively. The suggested sensors additionally demonstrated long-term stability and worked following preparation without significant changes in the potential or slope values, the analysis method is very sensitive and selective, and the t-test and F-test at a 95% confidence level were used to perform the statistics precisely and accurately.