Placental Growth Factor as a Diagnostic Glycoprotein in Preeclampsia

Abstract

Angiogenicfactor imbalance, such as that caused by placental growth factor(PLGF), is a feature of preeclampsia. However, the connection amony PLGF,clinical, laboratory indicators and the severity of preeclampsia is not entirely understood. Ninety subjects were incorporated in this study(The age range 17-40years),( 30)were healthy pregnant with mean age (26.57±1.07). (30)MildPreeclampsia cases with mean age (30.42±0.78)and (30)sever PE with mean age (33.32±1.09)wherever all women were more than 20 weeks of pregnancy. Mean blood pressure and level of proteinuria were used as indicators of the severity of the disease. ELISA was used to measure the levels of PLGF in the serum. Serum lipid profile were measured by enzymatic methods. The qualitative dip-stick technique was used to assess the amount of urine protein. A substantial difference between the PE group's serum PLGF concentration and that of the healthy subjects (p= 0.001)could be seen. Serum PLGF concentrations of patients with mild PE and those with severe PE differed significantly. Additionally, there were strong positive relationships between the serum PLGF concentration and the systolic BP and proteinuria serum PLGF levels, biochemical indicators, and other factors,however, did not significantly correlate. The diagnostic accuracy in distinguishing PE from the healthy patient group was good thanks to the excellent area under the curve (AUC = 0.83, p = 0.0001)In conclusion, Levels ofPLGFin area of PE patients were decreaed. PLGF was significantly correlated withPE patients.