Activity of Ciprofloxacin and Resveratrol on Expression of AdeI JGenes in Clinical Acinetobacter baumannii Isolates

Abstract

Acinetobacter baumanniiconsidered one important pathogenic bacteria and responsible for severalnosocomial and community infections for human and , possessthe ability to form biofilms , andcontinued development of antibiotic resistance to drugs used to treat bacterial infections.The currentstudy was performed ,during the period1/9 /2022to the end of December 30 /12 /2022 , a total of 210 blood specimens were collected in Baqubah Teaching Hospital /Iraq to investigate the prevalence of bacterial isolates among patients in Intensive Care Unit (ICU) , detect antibiotic resistance , biofilms formation , molecular detection of efflux pumps adeIJgenes , and activity of ciprofloxacin and resveratrol on expression of these two genes.The results revealed that the percentage of positive growth of A.baumannii,which isolates from blood samples with among ICU patients were 12 %, presence of the highest resistance of 25 isolates against fourteen types of antibiotics, our finding showed significant differences before and after treatment of resistance isolates with Resveratrol with a higher reduction expression of AdeIJgenes in all isolates under study reaching 0.59 and 0.28, respectively.