Evaluation of Minerals and some Biochemical parameters in the serum of Renal stones from Iraqi patients

Abstract

Urolithiasis is a Global health issue, a frequent and painful illness involving kidney or urinary tract stones. Anatomical, environmental, genetic, viral, metabolic, dietary, and socioeconomic variables are among its causes. There is a 50% chance of recurrence within five years, and the frequency varies between 4 and 20% worldwide. This study aims to correlate stone composition with blood biochemical parameters in urolithiasis patients. 85 blood samples were collected and divided between 45 patients with kidney stones and 40 controls. Urea, uric acid, creatinine, GFR, calcium, sodium, and phosphate were taken as effective parameters against the disease. presents a comparison between female patients with kidney stones and the control group, showing no statistically significant differences in age, weight, or GFR levels (p > 0.05). However, levels of urea, uric acid, creatinine, calcium, sodium, and phosphate were significantly higher in the patients (p < 0.05). comparison between male patients with kidney stones and the control group, levels of urea, uric acid, creatinine, and sodium were significantly higher in the patients (p < 0.05). The level of both Uric acid and creatinine is significantly high, in addition to electrolytes and calcium Increase in kidney stone disease. We note that urea, uric acid, and creatinine They are excellent indicators for detection Kidney stones because they are vital signs Kidney disease. As for electrolytes, represented by calcium, sodium, and phosphate, it depends mainly on nutrition and increasing their quantities, and this increase leads to their accumulation in the kidneys, and thus stones are formed.