Synthesis, Characterization and Biological activity of new Metal Complexes Derived From 4-Phenyl-3-thiosemicarbazide

Abstract

The study involved the synthesis and characterization of the new compound 4-methoxy-N-(2-(phenylcarbamothioyl) hydrazine-1-carbonothioyl) benzamide (L). By combining the title ligand with metal ions of manganese (II), cobalt (II), and nickel (II), three transition metal complexes were synthesized. This reaction occurred through the combination of metal and ligand in a mole ratio of one-to-one utilizing ethanol as the solvent. The complexes generated have a chemical formula as follows: [LMnCl₂.H₂O], [LCoCl₂H₂O], and [LNiCl₂.H₂O]. A variety of physicochemical techniques have been utilized to demonstrate the entity of the predicted structure of the ligand and its metal complexes. including Fourier transform infrared spectroscopy, UV-Vis spectroscopy, (1H and 13C)-NMR, elemental analysis (C, H, N, S), content of chloride, content of metal, m.p., the molar conductivity measurements, and also magnetic susceptibility. Based on spectral and analytical data, the isolation complexes for the manganese (II), cobalt (II), and nickel (II) exhibit a six-coordinate with a distorted octahedral geometry. The antibacterial activity of the complexes was investigated against (G+) and (G-) bacteria