Effect of L-Glutamic acid on histology and functions of Liver and kidney of Rats and Protective Role of Zingibar Officionale

Abstract

Background: Monosodium glutamate (MSG) or L-Glutamic acid is the sodium salt of glutamic acid is toxic to human and experimental animals. Liver and kidney may be susceptible to injury resulting from toxic substances. Ginger has immuno-modulatory, antitumorigenic, anti-inflammatory, anti-apoptotic, antihyperglycemic and anti-lipidemic actions. Objective: This study has been carried out to evaluate the protective effects of aqueous extract of Zingiber Officinale in decreasing and ameliorating effects of Monosodium glutamate induced alteration in hepatic and renal tissues and their functions of rats. Patients and Methods: Twenty four adult rats were divided into three equal groups and maintained under standard laboratory conditions. The ginger extract and the MSG were given orally once daily for 21 days. Group I Control: distilled water Group II: received MSG (4.0g/kg B.W) Group III: received 4.0g/kg B.W of MSG +100mg/Kg of ginger. After the last dose blood was collected. Results: Monosodium Glutamate /L-Glutamate caused loss of normal histological architecture of liver and kidneys of rats of Group II with significant changes in biochemical parameters compared with control groups (P < 0.0001). Zingibar Officinale /Ginger is an excellent antioxidant substance that ameliorated and prevented the toxic effect of MSG in a group III treated with combination of MSG and Ginger histologically and functionally. Conclusion: Zingibar Officinale (ginger) caused decrease the hepatotoxic and nephrotoxic effects resulted from oxidative damage induced by MSG because of their antioxidant effects.