Synthesis and Characterization of Some Pyrimidine Derivatives from Dimethyl Malonate and Evaluation their Biological Activity

Abstract

In this research of some new pyrimidine derivatives were synthesized by reaction of dimethyl malonate with different aldehydes (Cinnamaldehyde, Vanilline, Naphthaldehyde or Furfural) and urea, Thiourea or Thiosemicarbazide in three-component Biginelli reaction with good yield and signed as (A1-A10). These compounds were synthesized via microwave irradiation by using modified domestic microwave oven. Some of the newly synthesized compounds exhibited antibacterial and antifungal activity. The structure of the synthesized compounds were confirmed by physical and spectra 13C/1H-NMR and FTIR.