Glucose-6-Phosphate Dehydrogenase Deficiency among Neonate with Jaundice in Baquba city

Abstract

Background:Glucose -6-phosphate dehydrogenase (G6PD) deficiency is the commonest genetic disorder and is one of the most frequent red cell enzymopathies worldwide, Individuals with this disorder are prone to jaundice and hemolysis upon exposure to certain triggers, including fava bean consumption & certain drugs Objective:To determine the rate of G6PD deficiency among neonate with jaundice and in relation to certain epidemiological character in Baquba city. Patients and Methods: This cross sectional study includes (155) neonates from both sex, males (106) and females (49) From 1st February to 30th July 2018, in neonatal care unit in Albatool Teaching Hospital in Baquba city, the diagnosis was done by ELISA test to detect G6PD deficiency among neonate with jaundice. Results: Out of 155 neonates, showed male neonates & female neonate, 39 (97.5%), 1 (2.5%) respectively were found to have G6PD deficiency, the mean age among G6PD deficient and normal 3.0±1.6; 4.3±2.4 days respectively, with significant difference (P 0.001), the mean TSB level among G6PD deficient neonate, normal neonates were 17.4±3.55, 15.9±3.19 (mg/100 ml) respectively with significant difference (P 0.014). Conclusion: The rate of G6PD deficiency was (25.8%) among the studied neonates, It was discovered more among first, second and third age of life and it was more among male than female.