Synthesis a Series of 1,3,4-Thiadiazole Derivatives and Investigate Their Biological Activity

Abstract

Eight compounds of new 1,3,4-thiadiazole biologically active for the series1,4-di(5-(4- substitutedphenyldiazenyl)-1,3,4-thiadiazol-2-yl) benzene were prepared through the reaction of terephthalic acid with thiosemicarbazide .The product was coupled with substituted benzene through a diazotization reaction. The synthesized compounds (2-9) were identified using the analytical and spectral means. The biological activity for those compounds was investigated against three types of bacteria Escherichia coli (Gram negative bacteria), Enterobacter (Gram- negative bacteria) and Staphylococusaurens (Gram-negative).