Study of Effect of Methomyl on Some Hematological, Biochemical Parameters and Histological Changes in Male Albino Rats

Abstract

This study has been designed to study the effect of methomyl on hemodynamic, liver and kidney in rats. Methomyl compound (0.5, 1, and 2 mg/kg. bw) was orally administered once per a day during a period of 28 days of experiment. Results showed a significant(P<0.05) decrease in the level of WBC, HCT, MCHC and a non-significantdecrease in the level of RBC, HB, MCV, MCH, was observed in the methomyl group, while the level of PLT significantly increased in Methomyl group in comparison with control group. Non-significant decrease in a level of serum urea in all three groups of Methomyl, while serum creatinine level deceased non-significantly in group1 and group 2, but increased non-significantly in group3 of Methomyl when compared with control group.A Significant decrease in the level of HDL, with significant increase in the level of serum cholesterol, ALT and AST. A non-significant increase in the level of TG, LDL, VLDL and ALP of methomyl group when compared with control group. The Histology of liver of rat treated with 0.5,1 and 2, mg / kg bw.methomyl showed that dilation of central vein, sinusoids between hypertrophied hepatocytes and cytoplasmic vacuolization with loss of radial arrangement of cells, Meanwhile, kidney showed some changes including glomerular degeneration, tubular degeneration, hemorrhage, infiltration and glomerular shrinkage.