Synthesis of Some New Mannich Bases Containing Acetylenic Amines Derived from Piperazine

Abstract

In regard to the biological effectiveness of the piperazine and the acetylenic compounds derived from the secondary amines such as piperidine and morpholine. These acetylenic amines are very important class compounds for their pharmacological properties such as activity, low toxicity and fast absorption by body. More over these compounds are electron rich and easy to bond with protein receptor. A number of pharmacologically important acetylenic amines derived from piperazine with expected activity as oxotremorine antagonist have been synthesized through Mannich reaction(1). The compounds prepared by reaction of substituted propynes and butynes with substituted piperazine and paraformaldehyde in the presence of cuprous chloride as a catalyst. All the prepared compounds are characterized by elemental analysis, physical data and spectroscopic methods (IR, H1 -NMR), and physical and spectral data were tabulated showed in tables (1-3).