Immunological Defense Role of Oral Mucosa against Candidiasis Isolated from Human and Domestic Cats

Abstract

Background: Candida albicans (C. albicans) is an opportunistic fungus that infects the mucosa of oral cavity. Oral candidiasis remains one of the most common forms of Candida infections. Objective: To isolated C. albicans from oral cavity of human and cats and study which one was more virulence. Patients and Methods: C. albicans was collected by swabbing samples from oral mucosa to human and domestic cats. Mice injected with C. albicans isolated from human and cat divided to groups to study the immunological role. For each groups were divided depends of the time subjected to blood serum and tissue biopsy collected (6, 24 hours and 10 days) after mice injected with Candida. Measured IL-17, HMGB1 and G-CSF level in blood samples and tissue biopsy were done. Results: The concentration of IL-17 in a group of mice injected with isolated Candida from mouth of human showed a significant increase in the two times of draw ( 24h and 10 days), while the concentration of IL-17 in group of mice injected with isolated Candida from mouth of cat showed significant increase and this elevation was shown in the two times of tissue biopsy collection ( 6h and 24h).While the higher increase in the levels of serum HMGB-1 recorded in mice at 6h and 24h after injected with isolated Candida from mouths of cats. On another hand the result of the concentration of G-CSF in tissue biopsy showed decreased at 10 days compared with control group. Conclusion: Candida isolated from human more virulence form Candida isolated from.