Synthesis, Characterization of New Tridentate Schiff base Type (NOO) Derived From 4-aminoantipyrine and Glyoxylic Acid and it's Complexes with Some Metal Ions and Evaluation of their Antibacterial Activity

Abstract

The new tridentate schiff base type (NOO) namely ((1,5-Diemthyl-3-oxo-2-phenyl-2,3- dihydro-1H-pyrazol-4-ylimino) (HL) was prepared from condensation of 4-AAP and glyoxylic acid in ethanol as a solvent in presence of a few drops of 48% HBr as catalyst. The new schiff base ligand (HL) was reacted with some metal ions in ethanol to give a series of new metal complexes of two molecular formula: [VO(HL)2(SO4)].3H2O and [M(L)2].XH2O, (Where: M II =(Mn, X=3); (Co, X=2); (Ni, X=3); (Cu, X=2); (Zn, X=2); (Cd, X=2); (Hg, X=3); HL=C13H13N3O3, L= C13H12N3O3. All prepared compounds were characterized by spectroscopic methods (FT-IR, U.V-Vis, 1H-, 13C-NMR atomic absorption), elemental microanalysis C.H.N., magnetic susceptibility, molar conductivity along with melting point. From the data of all technique, the suggested geometrical structure for all prepared complexes were octahedral geometry. The new schiff base ligand (HL) and it's metal complexes were screened for their antibacterial activity against bacteria, staphylococcus aureus, Bacillus, Escherichia coli and pseudomonas aureus.