Synthesis and Study of Some New Histidine Derivatives

Abstract

In this work: Oxazole derivative (1) were prepared from reaction histidine with acetic anhydride ,which on treatment with thiosemicarbazide afford Schiff bases (2),and then two methods are used for Schiff bases fusion ,one of them fusion to obtained imidazole derivative (3) ,while the other method treatet with chloro ethyl acetate to obtained oxoimidazole derivative (4).Imidazole derivative(5) were prepared by fusion oxazole derivtive (1) with ophenylene diamine. Finally oxazole dreivative (1) treated with hydrazine hydrate gave imidazole derivative (6),which on treatment with aldehyde afford Schiff bases (7a,7b). The structure of the newly synthesized compounds was confirmed by M.p, elemental analysis, IR spectral data. All these synthesized compounds showed in Scheme (1)