Age- Related Changes In The Lipid Peroxidation And Antioxidant Systems of Male Subjects

Abstract

The effect of ageing on the lipid peroxidation and antioxidant system was evaluated in this study . for this purpose , we determined MDA as a marker of lipid peroxidation , reduce glutathione , uric acid as well as catalase and glutathione-s-transferase in serum of 84 male healthy individuals (non-smokers). These subject were divided in to three groups: group 1 ( n=28;25-34 years old) ; group2 ( n= 28;35-44 years old ); group3 (n= 28;45-63years old ). The result showed increased level of MDA and were observed as the stage of age increased (p >0.05). whereas there is a depletion in GSH level related to age increase ( p< 0.05), which indicate that the low level of GSH in the circulation may be due to their increased utilization to scavenge lipid peroxide. There was higher levels of catalase and GST in group3 compared with others. Group2 showed lower level in haemoglobin and higher level in albumin in compared with other groups (p<.0.05). no meaningful differences were found in terms of serum total protein and uric acid levels