Biochemical and histopathological effect of ketorolac on liver and kidney of local male rabbits

Abstract

Ketorolac is anti-inflammatory analgesic drug which have high activity to reduce pain, used in rabbits, primary in ocular operation. In current study, the aim of it to obvious the biochemical and histopathological effect caused by ketorolac on liver and kidney of the rabbits. Thirty local male rabbits were used, the rabbits divided equally and randomly into three groups, first control group, second group and third group ,each group consist of ten rabbits and the study continuous for 14 days. The Biochemical result of this study revel normal value in first control group, the second and third group showed significant increase in the liver enzyme, creatinine, bilirubin and nitrogen urea. Histopathological changes showed normal histological structures of liver and kidney in control group. Liver in second group showed cellular necrosis and hemorrhage at 15 mg/kg of ketorolac, while injection of 30 mg/kg in third group, the liver showed complete destruction of cell membrane. Kidney in second group showed hemorrhage at 15 mg/kg of ketorolac while injection of 30 mg/kg of ketorolac in third group, the kidney showed glomerular atrophy, bowman space dilation, collapsed tuft, degenerated tubules and cellular necrosis.