Detection of Public Health Risks of Cadmium Chloride Residues That Experimentally Injected in Albino Male Rabbits

Abstract

The proteins of animal consider important source for human nutrition include meats, liver and kidney that contents essential amino acids and other bioactive ingredients, Cadmium chloride which causes environmental pollution is a worldwide serious problem, the importance of current study to explain the effects of cadmium chloride accumulation in the liver and kidney which reflex the carcasses quality in polluted areas. ( 15 ) albino male rabbits were unsystematically and equal divided into three groups, 1st group considered control, 2nd group received single dose weekly 0.67 mg/kg of CdCl2 for 75 days, 3rd group received three doses weekly 0.67 mg/kg CdCl2 for 75 days, the blood samples were collected at day 75 of experiment for biochemical assay of serum total protein, serum urea, serum creatinine, Alanine amino transferase ( ALT ), Aspartate amino transferase ( AST ), Alkaline phosphatase ( ALP ). Also, liver & kidney samples were taken at 75 days for histopathological examination. The results in 2nd & 3rd group showed significant increase in total protein, urea, creatinine, AST and ALT while significantly decrease of ALP, the histopathological changes on liver in 2nd & 3rd group showed infiltration of inflammatory cells, vacuolation with necrosis of hepatocytes, while in kidney at 2nd & 3rd group showed tubular degeneration, severe necrosis of proximal tubules, these changes considered dangerous due to level of CdCl2 is elevated compared to normal limit in kidney and liver, consuming the meat and edible organs of farm animals that exposed cadmium contamination may be risk on human health and public health, according to the danger index.