Antimicrobial Activity of Copper Oxide Nanoparticles on Multidrug Resistant Bacteria MDR and C. albicans

Abstract

The increase of antimicrobial drug resistance of microorganisms and their harmful effect on human beings necessitate finding solutions and alternative methods to reduce the risk of this phenomenon. Nanoparticles have been focused on as an alternative method to prevent the spread of drug resistant microorganisms. Copper oxide nanoparticles (CuO-NP) were synthesized by Direct-Current (DC) plasma method. Polycrystalline monoclinic structures for CuO lattice consistent with the standard card No. 96-101-1195. The diffraction lines appeared at Bragg’s angles of (35.5565º, 38.7921º, 48.8611º, and 58.4383º) matching the planes (11-1), (111), (20-2), and (202) respectively. The SEM image showed homogeneous Small rods in size and shape in the sample of diameter about 20 nm and a length of about 78 nm. MDR bacteria and fungi were isolated from Baqubah teaching hospital in Diyala governorate. CuO-NPs showed antimicrobial activity of these pathogenic by visualizing the inhibition zone around the CuO-NPs disks.