Role Of Acrylonitrile Toxicity In Lung Albino Male Rats

Abstract

The aim of this study to investigate the effectiveness of Acrylonitrile ( AN ) in albino male rats, the rats ( n= 130 ) were randomly and equally into 2 group: 1st group act as control group feeding on rat diet, 2nd group administration daily orally by the stomach tube AN (40mg/ kg BW) for 90 days, AN was prepared by dissolving of 0.8 ml of AN in 100 ml of D.W. ( 0.8% v/v ). In 90 day of study taken the blood samples for serum Alpha fetoprotein ( AFP ) assay by Elisa tech-nique & lung tissue. Results indicated that AN significantly increased (P<0.05) in AFP concentra-tion, pathological changes showed peribronchial lymphoid proliferation with emphysema, inter-stitial pneumonia with alveoli fibrosis, necrosis and collapse of alveoli septa. In conclusion the AN showed intoxicant and induced pronounced hazardous effects and pathological changes in lung rats.