Clinical and Hematological Evaluation of The Midazolam, Xylazine and Ketamine as Anesthetic Regime in Donkeys

Abstract

Aims: The study aimed to evaluate the efficacy of midazolam, xylazine and Ketamine as balance general anesthetic procedure in donkeys. Methods: Six adult of local breed donkeys were used in current study. The animals were injected via jugular vein with midazolam 0.1 mg/kg of B.W., as premedication and after five minutes of midazolam administration, animals were injected intravenously with xylazine HCl 2% 1.1 mg / Kg of B.W and ketamine 2.2mg/Kg B.W respectively. Physiologic parameters were estimated in zero time as control and in 10, 20, 40, 75 and 120 minutes were including: respiratory rate with heart rate also body temperature was measured in zero time and in 40, 75 and 120 minutes and blood samples were collected at zero, 60, 120 and 180 minutes after anesthesia for findings hematological changes. Results: A mild decrease in rectal body temperature at 40, 75 minutes after anesthesia with significant difference and increased respiratory rate with substantial difference at 10 and decrease at 20, 40 minutes with significant difference and no significant difference at 75, 120 minutes after anesthesia . The heart rate revealed no significant differences after 10 minute and zero time but show significant difference between zero time and 75, 120 minutes. Hematological tests revealed slight variation with no significant changes in RBCs, WBC, HB and PCV, only WBCs after 180 minute showed a mild significant decrease compared to control values. Conclusion: the general anesthesia produced by this procedure was effective and had no impact on the physiological parameters in donkeys. It can be applied to this species for both induction and maintenance anesthesia.