Reducing the Negative Effects of Cadmium by Using Vitamin E , as an Antioxidant

Abstract

This study was done by using 200 Swiss mice, which had been divided into two main groups, each group contains (40 male + 60 female). The first main group had been treated with cadmium (cd+), while the other with cadmium and vitamin E (Vit E). Each main group had been divided into four subgroups, each one contains (10female + 15male). The first subgroup was regarded as control, which had free metals distilled water, while the three others subgroups were treated with D.W. which contain (10, 50, 100 ppm cd+) respectively. Also, the other main group were divided into four subgroups, the first one as control, while the others were treated with cd+ and Vit E. which were added to the drinking water in concentrations (10 ppm cd+ +50 ppm Vit. E, 50ppm cd+ + 50 ppm Vit. E and 100ppm+ cd+ +50 ppm Vit. E) respectively. After 8 weeks of treatment, half of males had been dissected for study from subgroups, the other half had mated (one male with three female). The study showed a significant weight loss as the concentration of cd+ increased in the first main group, while the results of the second main group that treated with cd+ and Vit. E, showed no loss of weight compared with control group. Also, cd+) had an obvious effect on weight, number and mortality of fetus in the fourteenth day pregnancy in the first main group, this effect increases of cd+ concentration, while there was no effect of cd+ and Vit.E. Results showed that number and activity of sperms had significant decrease, also results showed that cd+ had a great effect on apportion and causing falling of the seminiferous liquid quality.This study showed that Vit E had an effect to repair all destruction and protect body tissue from cd+ effects. Also, Vit E increase cell capacity to resist the oxidant effect of cd+ this may protect the reproductive system, this has been noticed in the increase weight average, sperm numbers, sperm activity, thus it will increase male fertility that treated with cd+ and Vit E. also in this group there was decrease in fetus mortality compare with the first group.