Spectrophotometric determination of Naproxen in the pharmaceutical Preparations Via Oxidative Coupling of Naproxen with Ansidine

Abstract

The development of a spectral method to estimate Naproxen by the oxidative coupling with the reagent of ansidine in the presence of oxidized agent N- Bromo succinimid in the acidic medium of Acetic acid to form a purple color soluble in water, showing a highest absorption at the λMAX 562 nm and according to Beer law in a concentration ranging between (1-28mg. ml-1). molar absorpitivity value reached 8.878*103L. mol-1 . cm-1 , Sandal sensitivity of 0.0350 mg cm-2 , the detection limit 0.045mg. mL-1, relative standard deviation of the method doesn’t exceed 1.24% the method has been successfully applied for the determination Naproxen in Tablets both the direct and standard additions methods ranged and found to be of 99.38-100.003%. A statistical treatment of results has been adopted using T and F at confidence interval 95℅ , to compare it with the results of standard addition method. The results of statistical treatment and showed there was no significant difference between both ways and ,as a result of that, the suggested method is valid for the application on pharmaceuticals.