Synthesis and Characterization of Some New 4-Oxothiazolidine-2- Carboxylic Acid Derivatives With the Evaluation of Their Biological Activity.

Abstract

Reaction of 2-alkylthiazolidine-4-carboxylic acid [1] with methanol in presense drops of sulfuric acid gave the ester: methyl 2-alkylthiazolidine-4-carboxylate [2], then converted this ester to the acid hydrazide: 2-alkylthiazolidine-4 carbohydrazide [3] which was reacted with glyoxylic acid to give Schiff base: 2-[2-(2-alkylthiazolidine-4-carbonyl)hydrazono]acetic acid [4]. Schiff, s bases (4) were reacted with thioglycolic acid to give 3-(2-alkylthiazolidine-4- carboxamido)-4- oxothiazolidine-2 - carboxylic acid [5]. The spectral methods of the prepared compounds were characterized by FT.IR, 1HNMR ( just for compounds 5), and Uv-Vis, besides melting points were recorded and the purity was checked through T.L.C. technique. Antibacterial activity for some of the synthesized compounds were screened.