Biochemical Study in Iraqian Patients with Chronic Renal Failure Therapy by Regular Hemodialysis

Abstract

In this study, we evaluated the mineral disorder and some biochemical parameters of kidney functions in Patients with end-stage renal failure. The aim of study is to assess the serum concentration of each (total calcium, phosphor, urea, creatinine, albumin and glomerular filtration rate (GFR) in patients suffering from chorine renal failure therapy by regular hemodialysis. This study has been carried out at the consultative clinic in Baquba / Ibn seena center for renal failure, for the period January 2016 to march, 2016. 75 specimens of each of patients and control groups were collected. Patients were divided into two study groups dependent on treatment period: (first) regulated hemodialysis less than year group and (second) regulated hemodialysis more than year group.The following biochemical investigations have been studied for their total calcium, phosphorus, urea, creatinine , and albumin which calculated by utilizing a ready-made laboratory kit for this purpose. A height in m and weight in kg were measured for all participant and BMI = weight / (height) 2 by same investigator and tools GFR can be calculated mathematically from the Modification of Diet in Renal Disease (MDRD) formula. The study showed an increase in creatinine (120.2±7 µmol/L) renal disease, urea (29.75±1.3mmol/L), phosphor (6.012±0.5mg/dl) concentration in the serum of patients group when compared with control group were creatinine (60±05µmol/L), urea (4.5±0.13mmol/L), and phosphor (2.98±1.3). The results also showed a decrease in the concentration of total calcium (3.55±1.01 mg/dl), and GFR (25.15±13 ml/min) compared with control group total calcium was (9.02±1 mg/dl) and GFR (123±5 ml/min). There were a negative correlation between GFR and each of (age, creatinine, uera and phosphor) in both patients groups. Also, there were a positive correlation between GFR and total calcium in both patient's groups. 43.4% of patients were in range of BMI less than 18 in second groups. This Study, which showed that decrease in total calcium levels and increased in phosphor levels in patients with chronic renal failure and hemodialysis process, may play an important role in improving kidney function for some biochemical variables for patients with chronic renal deficit less than year and patients' therapy by regular hemodialysis more than year may be increased weight loss.