Synthesis and Characterization of Some Metal Complexes with Mannich Bases Derived from Saccharin and Study their Biological Activity

Abstract

A new series of transition metal complexes of Mn(II), Fe(II), Co(II), Ni(II) and Cu(II) have been synthesized from Mannich bases of ligands (J1) and (J2) that derived from saccharin and formaldehyde with 4-nitro aniline(J1) and 4-bromo aniline (J2).All the complexes are characterized by physical methods ( C.H.N.S micro analysis and molar conductivity) and spectral methods (IR, UV-Visible and H1-NMR). The results shows that the complexes of the [M(L)Cl2(H2O)] where M= Mn(II), Fe(II), Co(II), Ni(II) and Cu(II) are tetrahedral structure except copper complexes have a square planer geometry. The biological activity of these complexes are studied with (Staphylococcus aureus) that gives a good activity while the ligands absent any activity.