Synthesis of Some new derivatives of Chalcones and Study biological activity

Abstract

In this research some new chalcon were prepared

Synthesis new derivatives of chalcones by condensing1-[4-(Ethyl-nonyl)-phenyl]-ethanone with appropriate aldehyde Synthesis two methods were used to the derivatives of chalcones , there are Ultra Sonic waves , and through the direct crushing without solvent in a porcelain mortar . These twomethods were unique in being very fast with high yield , Althoug the usuall methods were used to prepare compounds (1-5) Synthesis of new chalcones derivatives containing on the epoxide oxirane ring [ compounds (6-10)] , others contained bromine compounds (11-15) , urea derivatives [compounds (16-20)] , and hydrazine derivatives [compounds (21-25)] . The prepared compounds were identeficaluvingIR , UV and Nuclear Magnatic Resonance spectra for some of them . The biological activity of the prepared compounds was invejtigated and the prepared compound showed agood inhibition effect aginest some types of micro organisms .