The level of Dehydroepiandrosterone Sulfate Hormone in Iraqi Diabetic Patients with Nephropathy

Abstract

Diabetes Mellitus is a chronic and complex disease, requiring continued lifelong management aimed at reducing premature mortality and the high morbidity caused by chronic complications, one of the main causes of chronic renal failure is diabetic nephropathy. The responsive filtering system in the kidney becomes progressively destroyed after many years of diabetes. This study was conducted to establish relationship of Dehydroepiandrosterone sulfate (DHEA_S) level with increased risk factor of kidney damage in diabetic, diabetic nephropathy and control men. Eighty one subjects were divided in three groups were incorporated in this study, 32 were healthy control ,with mean age ( 54±0.34) years , 30 diabetic men with mean age (55±0.9) years, and 19 diabetic men with nephropathy with mean age ( 65±0.57) years. They were attended at Baquba Teaching Hospital. This investigation was carried out on serum sample to measure the concentrations of DHEA-S by using [Enzyme-Linked Immuno Sorbents by Assay [ELISA]] test using commercially available kits. In addition to that, serum creatinine, blood urea, albumin, fasting serum glucose (FSG), Glycohemoglobin (Hb1AC), systolic blood pressure (SBP), body mass index (BMI), diastolic blood pressure (DBP) , and the duration of disease were identified in the control and patients. The experimental results revealed that the mean value of DHEA-S concentration was none significantly decreased in diabetic comparing to the control group (p>0.005), while the level of DHEA-S concentration were decreased significantly in diabetic with nephropathy compared to healthy control subject (p<0.005). Also, low mean concentration of serum DHEA-S noticed in all groups of diabetic patients, and highly significant decrease in DHEA-S levels with advancing age in the studied groups. This finding had been proved by multiple regression model used in this study, which showed that the negative correlation found between age, and serum DHEA-S level. The concentration of the other parameters (blood urea and creatinine) increases in the serum of patient groups as compared to the control group, on other hands decreased albumin in patient groups as compared to the control group. In summary, there is a major association between DHEA-S levels and diabetic nephropathy. These conclusions promote that DHEA-S level inversely correlated with the progression of diabetic nephropathy in diabetic men. Also decrease in DHEA-S levels with advancing age in the studied groups suggest that apart from age being diabetic is related with lower mean value of this hormone.