Synthesis and Biological Activity Evolution of 5-amino-1,3,4-thiadiazole- 2- thiol Compound and Some Derivatives

Abstract

In this work , new of 5-amino-1,3,4-thiadiazole- 2-thiol derivatives were synthesized (S1- S19), through the reaction of 5-amino-1,3,4-thiadiazole- 2-thiol with p-hydroxy acetophenone to form azo dyes (S2), Chalcones were synthesized by reaction of compound (S2) with different aromatic aldehyde(S3-S6). Compounds (S7-S17) were finally synthesized by ring closure by hydrazine and some hydrazine derivatives . The newly synthesized compounds were confirmed by FT-IR-spectra and H1-NMR, and they showed good agreement with the proposed structures. Also the biological activity of some of the test compounds were investigated in vitro, against some bacterial.