Abnormal Uterine Bleeding: a Histopathological Study

Abstract

Background: Abnormal uterine bleeding (AUB) is considered as one of the most common and perplexing problems both to the patient and the gynecologist. Until the pathology underlying menorrhagia is accurately diagnosed, proper therapy is hardly possible. Objective: The objectives of the study were to determine the types and frequencies of pathologies in endometrial curettings of abnormal uterine bleeding & compare different endometrial pathologies in patient to age groups. Material and Methods: a retrospective study in which H&E sections of endometrial curretings of 152 patients were evaluated. Diagnosis was made by correlating the morphological findings with the clinical history. Results: Out of 152 cases of AUB, 61.8% were due to organic causes, while 33.5% were dysfunctional in nature and seven (4.6%) specimens were insufficient for diagnosis. Of the organic causes of AUB, Table (3), low grade endometrial hyperplasia was the most frequent cause (41.5%) then pregnancy-related bleeding (31.9%). The most common histologic pattern in DUB was proliferative phase endometrium 45.1%, followed by secretory pattern 21.6%. Conclusion: Our study on endometrial curettings in abnormal uterine bleeding revealed clustering of cases around Perimenopause.