Synthesis and Characterization of New Complexes of Schiff Bases Derived From two Drugs "Benzocaine and Isoniazid" with Metal Ions Hg+2, Cd+2 , and Evaluation their Biological Activity

Abstract

A new transition metal complexes of Hg+2, Cd+2 of Schiff bases derived of two drugs "Benzocaine, Isoniazid" were synthesized with molarity ratio (1:2) M:L. The synthesized compounds were characterized by physical and spectroscopic measurements (IR spectrum and proton NMR spectrum, elemental analysis C.H.N, Molar conductivity). The complexes which synthesized by reaction the derived ligand of Benzocaine with metal salts formed tetracoordinate complexes and the derived ligand of Isoniazid with metal salts formed hexacoordinate complexes. The Biological activity were evaluated for synthesized compounds against two types of bacteria E.Coli and S.aureus, most of complexes shown anti-bacterial activity